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Abstract #1503

Deformable Registration for Recovering Image Distortions in DWI MRI of the Prostate at 3T

Andriy Fedorov1, Luis Ibanez2, Kemal Tuncali1, Robert V. Mulkern1, 3, William M. Wells1, Clare Tempany, Fiona Fennessy1

1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2Kitware Inc, Clifton Park, NY, United States; 3Department of Radiology, Children's Hospital, Boston, MA, United States

There is strong evidence of the value in using multiparametric MRI (mpMRI) to characterize prostate cancer. However, quantitative analysis of mpMRI is challenging due to the differences in resolution and acquisition-related distortions, which are particularly strong while imaging prostate using endorectal coil placed in air-filled balloon at 3T. Herein we propose a non-rigid registration approach fine-tuned to compensate for such artifacts by incorporating the prior knowledge about the nature of the distortion into the method. We evaluate the robustness and accuracy of the approach, and employ it to quantify distortions present in the DWI MRI of the prostate.