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Abstract #1514

Dynamic Contrast Enhanced MR Imaging for the Assessment of Prostate Cancer Aggressiveness at 3T

Eline Vos1, Geert Litjens1, Thiele Kobus1, Thomas Hambrock1, Christina Hulsbergen-Van de Kaa2, Henkjan Huisman1, Tom Scheenen1

1Radiology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; 2Pathology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

Dynamic contrast enhanced MR imaging for retrospective assessment of prostate cancer aggressiveness was explored in fifty-one patients at 3T with histopathological Gleason scores of resected prostates as the gold standard. Calibration for pharmacokinetic modeling was done by using non-cancer peripheral zone tissue to estimate patient-specific arterial input functions. For semi-quantitative parameters LateWash and Relative Enhancement there was a significant difference between low aggressive and high aggressive prostate cancer in the peripheral zone. For quantitative parameters Ktrans, Kep and Ve there was no correlation with aggressiveness, however, they showed significant difference between non-cancer tissue and prostate cancer for the peripheral zone