Julio Crdenas-Rodrguez1, Christy M. Howison2, Terry O. Matsunaga3, Mark D. Pagel4
1Chemistry and Biochemistry, TheUniversity of Arizona Cancer Center, University of Arizona, Tucson, AZ - Arizona, United States; 2Arizona Research Labs, University of Arizona, Tucson, AZ, United States; 3Radiology, University of Arizona, Tucson, AZ, United States; 4Departments of Biomedical Engineering, Chemistry and Biochemistry , The University of Arizona Cancer, University of Arizona, Tucson, AZ, United States
The Reference Region Model has been proposed as an alternative method for evaluating DCE-MRI results without requiring an AIF, yet this method cannot account for changes in blood flow and hematocrit that affect the evaluation of vascular permeability. Instead of comparing DCE of a single contrast agent in two tissues, we propose a new model that compares two contrast agents in a single tissue, termed the Reference Agent Model. This report describes the selective detection of two 19F contrast agents in vivo under dynamic and multislice conditions, and opens the possibility of estimating the relative permeability of two CA because this new model is independent of blood flow and hematocrit.