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Abstract #1526

The Assessment of Cellular Packing Heterogeneity in Brain Tumors Using DSC-MRI

MAGNA25Natenael Semmineh1, C. Chad Quarles1

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

The use of DSC-MRI in brain tumors is known to be influenced by contrast agent extravasation, which can result in additional extravascular T1 and T2 * effects well after the contrast agent initial bolus has passed through tissue. By separating and quantifying these T1 and T2 * effects in the period of time after the contrast agents first pass we propose that a new metric, termed the extravascular susceptibility calibration factor (Ke), can be derived and used to assess cellular packing heterogeneity. In this study we demonstrate that Ke may be used to differentiate between tumor types with varying cellular features.