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Abstract #1527

Limitation of DCE-MRI in Xenograft Model Study

Septian Hartono1, Tong San Koh2, Quan Sing Ng2, Richard Ong2, Hung The Huynh2, Sidney Yu3, Sotirios Bisdas4, Laurent Martarello5, Choon Hua Thng2

1Nanyang Technological University, Singapore, Singapore; 2National Cancer Centre, Singapore, Singapore; 3Singapore General Hospital, Singapore; 4Eberhard Karls University, Tbingen, Germany; 5F. Hoffmann-La Roche, Switzerland

DCE-MRI has been used extensively in preclinical and clinical trials as a biomarker of drug effect. It is commonly assumed that a decrease in blood volume and blood flow is related to drug effect. This study examines the pitfall of such an assumption and illustrates decrease in perfused blood volume in untreated tumor as derived by DCE-MRI