Septian Hartono1, 2, Tong San Koh, 12, Quan Sing Ng2, Richard Ong2, Hung The Huynh2, Sidney Yu3, Sotirios Bisdas4, Laurent Martarello5, Choon Hua Thng2
1Nanyang Technological University, Singapore, Singapore; 2National Cancer Centre, Singapore, Singapore; 3Singapore General Hospital, Singapore; 4Eberhard Karls University, Tbingen, Germany; 5F. Hoffmann-La Roche, Switzerland
We aim to determine if DCE MRI is a sensitive enough technique to detect changes in fractional intravascular volume and blood flow after administration of a single dose of bevacizumab. The results showed that the effects of bevacizumab are dose-related. A more gradual drop of blood volume was observed in group treated with bevacizumab 1mg/kg. On the other hand, a steep drop of blood volume was observed in group treated with bevacizumab 10mg/kg. The results suggested potential of DCE MRI as a sensitive biomarker of microvascular density.