Abstract #1624

Thrombin-Inhibiting Perfluorocarbon Nanoparticles Manifest Versatile Inhibition and Contrast for Thrombosis

Jacob Wheatley Myerson¹, Li He², John Stacy Allen², Todd A. Williams², Douglas M. Tollefsen², Gregory M. Lanza,¹², Shelton D. Caruthers¹, Samuel A. Wickline,¹²

¹Biomedical Engineering, Washington University in Saint Louis, Saint Louis, MO, United States; ²Medicine, Washington University in Saint Louis, Saint Louis, MO, United States

Perfluorocarbon nanoparticles functionalized for thombin inhibition with Bivalirudin or PPACK were tested as an inhibitor of thrombin In Vitro and in acute thrombosis models. The particles significantly inhibited occlusive arterial thrombi. Via specific polyvalent binding to activated thrombin, the particles also manifested binding providing magnetic resonance contrast highlighting thrombi.