Abstract #1625

First In-Vivo Application of Heparin-Polynitroxide Derivatives for Labeling of Vascular Wall

Maxim Terekhov¹, Kurt Reifenberg², Alexander Scholz¹, Stefan Weber¹, Stefan Fischer¹, Vasilyi Sen'³, Valery Golubev³, Thomas Mnzel⁴, Andrei L. Kleschyov⁴, Laura Maria Schreiber¹

¹Section of Medical Physics, Radiology Department, University Medical Center Mainz, Mainz, Germany; ²Central Animal House, University Medical Center Mainz, Mainz, Germany; ³. Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russian Federation; ⁴II-Department of Medicine, University Medical Center Mainz, Mainz, Germany

Cyclic nitroxides (CNR) are stable free radicals with multiple applications in MRI. Heparin is known to have a high affinity for the vascular extracellular structures. We propose that CNR could be delivered to the vascular wall by means of heparin-polynitroxide (HPR) derivatives where the nitroxide is linked with the heparin macromolecule. The first in-vivo studies show that high molecular HPN exhibits the long-lasting in-vivo life time and bind irreversibly to the inner layer of vascular wall, where they can be visualized both by EPR and MR techniques.