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Abstract #1655

Quantitative Molecular Imaging of Fluorinated Agents: 19F Flip Angle Calibration Using 1H Power Settings

Matthew J. Goette1, Gregory M. Lanza1, Samuel A. Wickline1, Shelton D. Caruthers1

1School of Medicine, Washington University in St. Louis, St. Louis, MO, United States

This study presents a strategy to more accurately quantify the sparse 19F signal from perfluorocarbon nanoparticle emulsions through flip angle calibration utilizing the abundant 1H signal. We hypothesize that the RF power settings optimized for 1H can be used to determine the correct RF power settings for the 19F signal acquired with 19F/1H dual-tuned coils on a 3 T clinical scanner. Flip angle sweep experiments using two types of dual-tuned coils were performed, which showed that a coil-specific, but spatially-independent calibration value can be determined to set the correct 19F power settings using the 1H signal.