Evaluation of Lung Metastatic Tumor Using Dextran-DTPA-Mn Nanoprobes with Ultra-Short Echo-Time Imaging

Daisuke Kokuryo¹, Jun-ichiro Jo¹, Tsuneo Saga¹, Ichio Aoki¹

A newly developed manganese-nanoprobe (Dextran-DTPA-Mn) and three-dimensional ultra-short echo-time (UTE) imaging was applied to evaluate a lung metastatic tumor model. Comparison was made with a conventional Gd-DTPA contrast-agent as a control. The Dextran-DTPA-Mn signal in the lung parenchyma increased immediately after administration and was thereafter maintained for 24 hours. The tumor region in lung parenchyma was enhanced by the accumulation of Dextran-DTPA-Mn. The Dextran-DTPA-Mn with UTE imaging will allow optimized chemotherapy using tumor-targeting nanoprobes.