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Abstract #1676

Sensitivity of Hyperpolarized 13C Kinetic Modeling to Flip Angle and Number of Temporal Samples

Matthew Smith1, Jeremy Gordon1, Dave Niles1, Kevin Johnson1, Sean Fain1, 2

1Medical Physics, University of Wisconsin, Madison, WI, United States; 2Radiology, University of Wisconsin, Madison, WI, United States

Dynamic imaging of hyperpolarized 13C with MRI provides metabolic kinetics with spatial localization in-vivo but is challenging because both T1 and RF decay reduce the hyperpolarized signal throughout the experiment. A low flip angle is typically used to mitigate RF decay and enable acquisition of many images by sacrificing image SNR. The simulations presented in this study investigate the kinetic modeling accuracy for a variety of flip angles and number of acquired images using a centric Cartesian trajectory and provides a target SNR for dynamic images.