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Abstract #1678

Synthesis of Hyperpolarized Ethanol Via PHIP

Thomas Trantzschel1, Ute Bommerich2, Markus Plaumann1, Denise Lego2, Torsten Gutmann3, Tomasz Ratajczyk3, Sonja Dillenberger3, Gerd Buntkowsky3, Joachim Bargon4, Johannes Bernarding1

1Dep. for Biometry and medical Informatic, Otto-von-Guericke University Magdeburg, Magdeburg, Germany; 2Leibniz Institute for Neurobiology, Magdeburg, Germany; 3Technical University Darmstadt, Germany; 4University Bonn, Germany

Parahydrogen Induced Polarization (PHIP) gains much attention as it is already used for metabolic studies in MR. Because of keto-enol tautomerism, molecules with a hydroxyl group next to double or triple bonds are not accessible via PHIP e.g. vinyl alcohol which is precursor for ethanol. Our study presents the first time an approach to generate PHIP hyperpolarized ethanol that is probably the mostly used psychoactive drug.