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Abstract #1691

In Vivo Real-Time Metabolic Studies in Mice at Physiological Concentrations Following 1-13C Lactate Injection

Yuhei Takado1, Mor Mishkovsky1, 2, Tian Cheng1, 3, Rolf Gruetter1, 2, Arnaud Comment1, 3

1LIFMET, EPFL, Lausanne, 1015, Switzerland; 2Department of Radiology, University of Lausanne, Lausanne, Switzerland; 3Institute of Physics of Biological Systems, EPFL, Lausanne, Switzerland

The real-time metabolic transformation of lactate in the mouse head was monitored following the injection of hyperpolarized 1-13C lactate at physiological doses. The results were compared with metabolic studies performed with hyperpolarized 1-13C pyruvate at similar blood concentration. From the observation that the lactate to alanine ratio was nearly identical following both the pyruvate and the lactate injections, we concluded that the substrate and its metabolites can be detected in real time at physiological concentrations after the injection of lactate.