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Abstract #1694

Metabolism of Hyperpolarized [1-13C]Pyruvate in the Isolated Perfused Rat Lung an Ischemia Study

Stephen Kadlecek1, Benjamin Pullinger1, Kiarash Emami1, Harrilla Profka1, Masaru Ishii2, Rahim Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

Difficulties with NMR studies of lung arising from low tissue density and air-tissue interfaces can be partially overcome using 13C-DNP NMR. This experiment studies the evolution of the [1-13C] lactate signal in isolated, perfused rat lungs after injection of pyruvate under normoxic and ischemic conditions in order to understand changes in lung oxidative state, central to ischemia-reperfusion injury, transplantation, and metabolic changes in cancer.