Abstract #1693

Evaluation of the Progression of Obstructive Nephropathy in a UUO Mouse Model Using BOLD, Hyperpolarized 13C, and DCE MRI

David J. Niles¹, Jeremy W. Gordon¹, Matthew R. Smith¹, Shannon Reese², Arjang Djamali², Elizabeth A. Sadowski³, Sean B. Fain¹,³

¹Medical Physics, University of Wisconsin, Madison, WI, United States; ²Medicine, University of Wisconsin, Madison, WI, United States; ³Radiology, University of Wisconsin, Madison, WI, United States

Obstructive nephropathy is the most common cause of end-stage renal disease in children. Currently we have a poor understanding of its pathogenesis, prognosis, and the best course of treatment. Non-invasive, non-radioactive diagnostic approaches are desirable. In this study we used MRI to monitor renal function during obstructive nephropathy in a 14-day unilateral ureteral obstruction (UUO) mouse model. Blood oxygen level-dependent (BOLD), dynamic contrast-enhanced (DCE), and hyperpolarized [1-¹³C] pyruvate (¹³C) MRI were used to assess renal oxygenation, perfusion, and pyruvate metabolism, respectively. The results show the potential of using functional MRI, particularly ¹³C MRI, to track the progression of obstructive nephropathy.