Abstract #1741

High Sensitivity Detection of Targeted PFOB Nanoparticles Binding in a Carcinoma Mouse Model Using a New Diffusion-Weighted Spectroscopy Sequence

Cline Giraudeau¹, Odile Diou², Nicolas Tsapis², Philippe Robert³, Caroline Robic³, Marc Port³, Denis Le Bihan¹, Sbastien Mriaux¹, Fawzi Boumezbeur¹, Franck Lethimonnier¹, Julien Valette¹,⁴

¹NeuroSpin, I2BM, Commissariat l'Energie Atomique, Gif-sur-Yvette, France; ²Univ Paris Sud, UMR CNRS 8612, Chtenay Malabry, France; ³Guerbet, Research Division, Roissy-Charles de Gaulle, France; ⁴MIRCen, I2BM, Commissariat l'Energie Atomique, France

In the present work, an original spectroscopy sequence dedicated to PFOB and composed of a diffusion-weighted LASER module followed by an echo train is used to specifically detect angiogenesis in a carcinoma mouse model. We show that this sequence is more sensitive than a conventional LASER sequence and allows detection of sub-nanomolar concentrations of _v₃-targeted PFOB nanoparticles. By selectively suppress signal coming from nanoparticles in the bloodstream, diffusion allows specific detection of angiogenesis on an individual animal. This method could be a novel concept to detect disease biomarkers by indicating the specificity of the signal provided by imaging.