Abstract #1742

Elimination of Frequency-Modulated Sideband Artifacts for in vivo Non-Water Suppression MRS

Jyh-Miin Lin¹, Tzu-Chao Chuang², Wen-Chau Wu³, Hsiao-Wen Chung⁴,⁵, Shang-Yueh Tsai⁶,⁷

¹Department of Radiology, Duke University Medical Center, Durham, NC, United States; ²Department of Electrical Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan; ³Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan; ⁴Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan; ⁵Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; ⁶Graduate Institute of Applied Physics, National Chengchi University, Taipei, Taiwan; ⁷Research Center for Mind, Brain and Learning, National Chengchi University, Taipei, Taiwan

In Vivo MR spectra without solvent suppression often incur poor spectral quality due to gradient-induced frequency modulation(FM). We invented an algorithmic method to identify and eliminate these artifacts. Advanced algebraic tool was introduced to separate symmetric peaks with opposite phases from metabolites and baseline. Based on time-domain methods, the amplitude contaminated by FM components are adjusted according to the diagonal elements of matrices which have been triangularized. Our result shows improvement of spectral quality and quantitatively lower biases. This method may be easily integrated into the processing programs, whereas the sequence and experimental design can remain similar.