Jeff Snyder1, Thomas Lange1
1Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany
A method to detect γ-aminobutyric acid (GABA) in vivo is presented based on subtraction spectroscopy. The method (JET) requires no special selective pulses and is based on flip angle variation in PRESS. The technique was tested in healthy subjects at 3 T with quantification analysis by LCModel and compared to the MEGA editing sequence. The Cramer-Rao lower bounds for GABA illustrated increased detection accuracy for JET (11%) as compared to MEGA (14%), signifying JET as a viable GABA detection method.