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Abstract #1751

In Vivo Absolute Quantification for Mouse Brain Tumor Using an Inductively Coupled Synthetic Signal Injection Method

Donghoon Lee1, Kenneth Marro1, Mark Mathis1, Eric Shankland1, Cecil Hayes1, Stacey Hansen2, James Olson2

1Department of Radiology, University of Washington, Seattle, WA, United States; 2Fred Hutchinson Cancer Research Center, Seattle, WA, United States

We obtained robust estimates of 31P metabolite content in mouse brain tumor using a synthetic signal injection method and an optimized, 1H/31P dual tuned probe. 31P metabolite concentrations were determined for brain tumors in a genetically engineered mouse model of medulloblastoma. The dual tuned 1H/31P probe was composed of a half volume coil and a second coil to allow injection of pseudo signals. In addition to in vivo 31P metabolite quantitation, 1H MR imaging was conducted to identify brain tumor and to determine tumor volume prior to 31P MRS.