Christine Sandra Bolliger1, Chris Boesch1, Roland Kreis1
1Depts Clinical Research and Radiology, University Bern, Bern, Switzerland
A method to optimize 2DJ experiments is presented. It is aimed at quantification of a set of metabolites and is based on searching acquisition parameters that yield minimal Cramer Rao Minimum Variance Bounds (CRBs). We present optimized experiments for GABA, glutamate, glutamine and glutathione quantification in human gray matter.