Decreased Cerebral Metabolism in Mice Exposed with Alcohol During Developmental Period

Anant Bahadur Patel¹, Vivek Tiwari¹, Dev Ketan Thacker¹

Brain development continues throughout gestation and postnatal period. As alcohol binds to glutamate and GABA receptors, exposure of alcohol during prenatal and postnatal period might affect the development of neurons and associated functions. Current study investigates the glutamatergic and GABAergic metabolism in the pups at P25 age obtained from dams exposed with alcohol during prenatal or postnatal period by using ¹H-[¹³C]-NMR spectroscopy in conjunction with infusion of [1,6-¹³C₂]glucose. Both, prenatal and postnatal exposure of alcohol to pups led to a reduction in glucose oxidation and neurotransmission associated with glutamatergic and GABAergic neurons.