Meeting Banner
Abstract #1818

Rapid Multi-Echo Measurement of Brain Metabolites T2 Values at 7T Using a Single-Shot Spectroscopic CPMG Sequence and Priors

Ece Ercan1, Andrew Webb1, Itamar Ronen1

1C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

We present a rapid method for the robust and accurate estimation of brain metabolite relaxation rates based on a single-shot CPMG sequence with multiple echoes. Each echo consists of a small number of acquired time-domain points. These truncated data sets are subsequently extended with additional data points calculated via solving a set of linear equations for the peak amplitudes using previously estimated frequencies and linewidths as priors. These priors are obtained from a short single volume MRS experiment with subsequent linear prediction using singular value decomposition (LPSVD) processing.