Abstract #1817

Proton T1 Relaxation Times of Metabolites in Human Occipital White Matter and Grey Matter at 7T

Lijing Xin¹, Benoit Schaller², Vladimir Mlynarik², Huanxiang Lu³, Rolf Gruetter,¹²

¹Department of Radiology, University of Lausanne, Lausanne, Switzerland; ²Laboratory of functional and metabolic imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; ³Institute of Surgical Technologies and Biomechanics, University of Bern, Switzerland

In this study, T₁ relaxations of ¹H resonances (singlets and J-coupled peaks) of brain metabolites in occipital white matter and grey matter were measured at 7T using an inversion recovery semi-adiabatic SPECIAL sequence. T₁ values of metabolites ranged from 900-2100ms and those of GSH, scyllo-Ins, Tau and NAAG were determined for the first time. T₁ of NAA, tCho, Glu and NAAG were significantly different in WM and GM. The reported values will be useful for the quantification of metabolites by MR spectroscopy at 7T.