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Abstract #1816

Brain Atrophy in MS Patients Correlates with Creatine Concentrations

Anders Tisell1, 2, Olof Dahlqvist Leinhard1, 2, Jan Bertus Marcel Warntjes1, 2, Anne-Marie Landtblom3, 4, Peter Lundberg, 25

1Division of Radiological Sciences, Department of Medicine and Health Sciences, Linkping University, Linkping, Sweden; 2Center for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden; 3Neurology, Department of Clinical and Experimental Medicine, Division of Neuroscience, Linkping University, Linkping, Sweden; 4Neurology Clinic, UHL, County Council of stergtland, Linkping, Sweden; 5Depts of Radiation Physics, Linkoping University and Radiation Physics, UHL County Council of stergtland, Linkping, Sweden

Absolute quantitative MRS and quantitative MRI was used to assess the difference of NAWM between MS patients with non or a low number of MS lesions, MS patient with MS lesions, and healthy controls. Elevated levels of total glutamine + glutamate was observed in both investigate phenotypes of MS compered to healthy controls. In contrast elevated myo-Inositol, Choline containing compounds and lower levels of N-acetyl aspartate glutamate was only observed in NAWM of MS patients with several lesions. Furthermore a correlation between atrophy and increased total creatine + phosphocreatine was also observed in NAWM of MS patients.