Abstract #1815

Scyllo-Inositol Detection in the Human Spinal Cord

Andreas Hock¹, Fuchs Alexander¹, Erin L. MacMillan², Roland Kreis², Spyros S. Kollias³, Peter Boesiger¹, Anke Henning¹

¹University and ETH Zurich, Institute for Biomedical Engineering, Zurich, Switzerland; ²University of Bern, Dept. of Clinical Research, Bern, Switzerland; ³Institute of Neuroradiology, University Hospital of Zurich, Zurich, Switzerland

Scyllo-Inositol (sI) is one of the stereoisomers of inositol yielding to a singlet resonance at a chemical shift of 3.35 ppm in 1H MR spectroscopy (MRS). This work represents the first report of sI detection in the human spinal cord, which was enabled by non-water suppressed metabolite cycled 1H MRS at 3T. The results show an increased mI/Creatine and sI/Creatine ratio compared to the brain which might be an indicator of a different metabolism in the spinal cord.