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Abstract #1815

Scyllo-Inositol Detection in the Human Spinal Cord

Andreas Hock1, Fuchs Alexander1, Erin L. MacMillan2, Roland Kreis2, Spyros S. Kollias3, Peter Boesiger1, Anke Henning1

1University and ETH Zurich, Institute for Biomedical Engineering, Zurich, Switzerland; 2University of Bern, Dept. of Clinical Research, Bern, Switzerland; 3Institute of Neuroradiology, University Hospital of Zurich, Zurich, Switzerland

Scyllo-Inositol (sI) is one of the stereoisomers of inositol yielding to a singlet resonance at a chemical shift of 3.35 ppm in 1H MR spectroscopy (MRS). This work represents the first report of sI detection in the human spinal cord, which was enabled by non-water suppressed metabolite cycled 1H MRS at 3T. The results show an increased mI/Creatine and sI/Creatine ratio compared to the brain which might be an indicator of a different metabolism in the spinal cord.