In-Young Choi1, 2, Ping-Chang Lin1, Wen-Tung Wang1, Phil Lee1, 3
1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2Neurology, University of Kansas Medical Center, Kansas City, KS, United States; 3Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States
Diabetic ketoacidosis is a serious condition characterized by elevated levels of ketone bodies that may lead to diabetic coma or even death in patients, particularly, with type-1 diabetes. Detection of changes in ketone body levels in the brain should help to detect ketoacidosis in hyperglycemic state. In this study, we identified a cerebral acetone signal at 2.22 ppm and significantly elevated levels of both acetone and beta-hydroxybutyrate (bHB) along with the elevation of glucose concentration in a rat model of streptozotocin-induced diabetes using 1H MRS at 9.4T. A moderate correlation between bHB and acetone was also observed.
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