Noninvasive Detection of 2-Hydroxyglutarate in Gliomas by 1H MR Spectroscopy at 7.0 T in vivo

Changho Choi¹, Sandeep Ganji¹, Abhishek Banerjee¹, Ivan Dimitrov¹, Ralph DeBerardinis¹, Craig Malloy¹, Bruce Mickey¹, Robert Bachoo¹, Elizabeth Maher¹

Mutations in isocitrate dehydrogenase (IDH) 1 and 2 in the majority of WHO grade-2 and -3 gliomas and secondary glioblastomas lead to production of 2-hydroxyglutarate (2HG) and are associated with longer overall survival compared to IDH wild-type gliomas. Here we report preliminary in-vivo 2HG measures by 1H-MR spectroscopy at 7 T. The echo time of PRESS was optimized as 92 ms for detection of the 2HG multiplet at 2.25 ppm. The performance of this optimized TE PRESS is discussed together with short TE PRESS (34 ms).