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Abstract #1813

Noninvasive Detection of 2-Hydroxyglutarate in Gliomas by 1H MR Spectroscopy at 7.0 T in vivo

Changho Choi1, Sandeep Ganji1, Abhishek Banerjee1, Ivan Dimitrov1, Ralph DeBerardinis1, Craig Malloy1, Bruce Mickey1, Robert Bachoo1, Elizabeth Maher1

1University of Texas Southwestern Medical Center, Dallas, TX, United States

Mutations in isocitrate dehydrogenase (IDH) 1 and 2 in the majority of WHO grade-2 and -3 gliomas and secondary glioblastomas lead to production of 2-hydroxyglutarate (2HG) and are associated with longer overall survival compared to IDH wild-type gliomas. Here we report preliminary in-vivo 2HG measures by 1H-MR spectroscopy at 7 T. The echo time of PRESS was optimized as 92 ms for detection of the 2HG multiplet at 2.25 ppm. The performance of this optimized TE PRESS is discussed together with short TE PRESS (34 ms).