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Abstract #1823

Reduced Glucose Oxidation by Glutamatergic Neurons in Cerebral Cortex During Normal Aging in Mice

Anant Bahadur Patel1, Pandichelvam Veeraiah1, Mohammad Shameem1, Vivek Tiwari1

1NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India

Changes in mitochondrial function at the cellular level is not fully understood under normal aging. Present study investigates glucose oxidation by glutamatergic and GABAergic neurons, and neurotransmitter cycling in adult and aged mice. Cortical glutamate level was found to be reduced in aged mice. The glucose oxidation by glutamatergic neurons was decreased in aged mice while GABAergic functions seems to be unperturbed.