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Abstract #1826

1H-MRS Changes in the Rat Brain Due to Circadian Cycle

Serguei Liachenko1, Jaivijay Ramu1

1NCTR / FDA, Jefferson, AR, United States

Circadian clocks regulate many physiological processes in biological systems. The diurnal changes in these processes may result in different sensitivity to pharmacological intervention as well as to the toxicity. Current study investigated the diurnal differences in neurometabolic profiles of nave adult rats using proton MRS