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Abstract #1827

High Resolution Spectroscopic Imaging of the Mouse Brain Using a Cryogenic 2x2 Phased Array Coil at 9.4T

Aline Seuwen1, Sandra Brgi1, Aileen Schrter1, Markus Rudin2, 3

1Institute for Biomedical Engineering, University and ETH , Zrich, Switzerland; 2Institute for Biomedical Engineering, University and ETH, Zrich, Switzerland; 3institute of pharmacology and toxicology, University Zrich, Switzerland

Spectroscopic imaging (SI) on the mouse brain is an attractive tool to quantitatively determine brain metabolite concentrations on different models of human diseases. However, SI suffers from low signal-to-noise ratio and long acquisition times, which restrain the practically achievable spatial resolution. In this work, a novel receive-only cryogenic phased array coil was used to overcome those issues. Using this setup, we could acquire spectra of excellent quality on a mouse model of glioblastoma at resolutions of 0.32 μl per voxel in less than 2h.