Abstract #1830

Effect of Cell Membrane Water Permeability on Diffusion-Weighted MR Signal: A Study Using Expression-Controlled Aquaporin4 Cells

Takayuki Obata¹, Jeff Kershaw², Daigo Kuroiwa¹, Sayaka Shibata², Abe Yoichiro³, Masato Yasui³, Ichio Aoki²

¹Center for Charged Particle Therapy, National Institute of Radiological Sciences (NIRS), Chiba, Japan; ²Molecular Imaging Center, NIRS; ³Department of Pharmacology, Keio University, Tokyo, Japan

We performed multi-b-value and multi-diffusion-time DWI on AQP4-nonexpressed (noAQ) and AQP4-expressed (AQ) cells to investigate the effect that CMP has on diffusion-weighted magnetic resonance signal. Significant signal differences between the noAQ and AQ cells were observed only at high b-values. Diffusion-time dependent ADC changes were also observed, but there were no significant differences between the noAQ and AQ cell samples.