Takayuki Obata1, Jeff Kershaw2, Daigo Kuroiwa1, Sayaka Shibata2, Abe Yoichiro3, Masato Yasui3, Ichio Aoki2
1Center for Charged Particle Therapy, National Institute of Radiological Sciences (NIRS), Chiba, Japan; 2Molecular Imaging Center, NIRS; 3Department of Pharmacology, Keio University, Tokyo, Japan
We performed multi-b-value and multi-diffusion-time DWI on AQP4-nonexpressed (noAQ) and AQP4-expressed (AQ) cells to investigate the effect that CMP has on diffusion-weighted magnetic resonance signal. Significant signal differences between the noAQ and AQ cells were observed only at high b-values. Diffusion-time dependent ADC changes were also observed, but there were no significant differences between the noAQ and AQ cell samples.