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Abstract #1841

Diffusion in the Extra-Cellular Space of the Rat Cerebral Cortex Probed by MRI and Direct Infusion of Contrast Agents

Gisela E. Hagberg1, Ilgar Mamedov1, Anthony Powers1, Michael Beyerlein1, Hellmut Merkle2, Goran Angelovski1, Nikos K. Logothetis1

1MPI Biological cybernetics, Tubingen, Germany, Germany; 2LFMI-NINDS, National Institutes of Health, Bethesda, MD, United States

Measurements of the diffusion properties of substances in the cerebral extra-cellular space (ECS) can be used to study drug delivery/clearance and brain tissue structure. Currently used methods have high sensitivity, but are limited to single spatial points or are performed post mortem, or has a limited depth penetration. Here we explore the use of MRI during direct infusion of T1 relaxating agents and mathematical modelling for investigating ECS diffusion.