Abstract #1865

The Association of Elevated Body Mass Index with Reduced Fractional Anisotropy Using Tract-Based Spatial Statistics and Tract-Specific Analysis

Keigo Shimoji¹, Shigeki Aoki¹, Osamu Abe², Takanori Uka³, Yoshifumi Tamura⁴, Koji Kamagata¹, Koichi Asahi¹, Masaaki Hori¹, Atsushi Nakanishi¹, Yasmin Hasina¹

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan; ²Department of Radiology, Nihon University Graduate School of Medicine, Tokyo, Japan; ³Department of Neurophysiology, Juntendo University Graduate School of Medicine, Tokyo, Japan; ⁴Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan

We explore the regional pattern of white matter alteration in metabolic subjects. In addition, we investigate whether white matter alteration was related to BMI. TBSS analysis revealed significantly lower FA values in metabolic subjects compared to normal control subjects in the part of the right external capsule, the entire corpus callosum and part of deep white matter of the right frontal lobe. By using tract-specific analysis, the mean FA value of right inferior fronto-occipital fasciculus was significantly lower in metabolic subjects compared with normal control subjects. A significantly statistical negative correlation was observed between BMI and FA values of right inferior fronto-occipital fasciculus.