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Abstract #1866

Mapping Microstructural Correlations of White Matter in the Human Brain Using Seed-Voxel Correlation Analysis of DTI

Charvi Shetty1, Yi-Ou Li1, Julia Owen1, Matthew Malter Cohen2, BJ Casey2, Pratik Mukherjee1

1Radiology, UCSF, San Francisco, CA, United States; 2Sackler Institue for Developmental Psychobiology, Weill Medical Colege of Cornell University, New York, NY, United States

In this work, we use seed-voxel correlation (SVC) as a means to assess the microstructural correlations between white matter tracts in the normal, adult brain. We compare our results with SVC to those obtained with independent component analysis (ICA), as previously published. We find 36 similar pairs of maps and we are able to uncover frontal fiber tracts not found previously. The results reveal that ICA and SVC yield complimentary, as well as, overlapping maps of spatially correlated white matter tissue.