Michael A. Chappell1, 2, Amit Mehndiratta1, Stephen J. Payne1, Fernando Calamante3
1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom; 2FMRIB Centre, University of Oxford, Oxford, United Kingdom; 3Brain Research Institute, Florey Neuroscience Institutes, Melbourne, Victoria, Australia
Macro vascular (MV) contamination from contrast agent in major arteries is a significant source of bias in Dynamic Susceptibility Contrast (DSC) perfusion measurements. In this work we propose a model-based approach for MV correction that includes a MV component within a previously proposed vascular model for DSC data.