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Abstract #1951

Comparison Study of T2* Effects on DCE-MRI and T1 Effects on DSC-MRI Between Brain Tumor and Normal Brain Tissue

Haoyu Wang1, Yanming Yu2, Jiani Hu3, E. Mark Haccke3, Wei Xing4, Shanglian Bao1

1Beijing Key Lab of Medical Physics and Engineering, Peking University, Beijing, China; 21Logging technique research institute, great wall drilling company, China National Petroleum Corporat, Beijing, China; 3Department of Radiology, Wayne State Univerisity, Detroit, MI, United States; 4Department of Radiology, Third Affiliated Hospital, Suzhou University, Changzhou, Jiangsu, China

Dual-echo pulse sequence has been proposed to simultaneously acquired T1 - DCE and T2* - DSC MRI. However, there is no comparative investigation of T2* effects on permeability and T1 effect on perfusion between normal and tumor tissues of brain. The goal of this work is to fill the gap. Preliminary results show that the difference of relative rCBV for healthy tissue with and without T1 correction is about 20%, but for tumor it is about 153%. The results indicate that T2* effects on permeability and T1 effects on perfusion are much greater in tumor than in normal brain tissue.