Marcel Oei1, Bozena Goraj1, Anton Meijer1, Jan-Jurre Mordang1, Albert Idema2, Sandra Boots-Sprenger3, Hendrik Laue1, 4, Mathias Prokop1
1Radiologie, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 2Neurosurgery, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 3Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 4Fraunhover Mevis, Bremen, Germany
rCBV values are normalized to an internal reference standard. The normalization step of rCBV calculation is subjective and introduces variability. 2 observers measured rCBVtumor derived from DSC-MR images in 17 glioma patients on 2 occasions. rCBV was normalised using 6 internal reference standards of normal apearing white and gray matter. Inter- and intraobserver reproducibility were quantified with intraclass correlation coefficient (R) and the coefficient of variation (CV). Inter- and intraobserver CV ranged from 7% - 17%. ICC showed good intra- (R=.69-.85) and interobserver variability (R=.76) for contralateral putamen. The least added variability was gained by normalization in the contralateral putamen.
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