Natenael B. Semmineh1, Junzhong Xu2, Jerry Boxerman3, C Chad Quarles2
1institute of imaging science, vanderbilt university, nashville, TN, United States; 2institute of imaging science, Vanderbilt university; 3Alpert Medical School of Brown University
Brain tumor DSC-MRI studies can be confounded by extravascular T2* effects that occur when the contrast agent extravasates. The resulting signals are consequently influenced by the extravascular compartmentalization of the contrast agent and therefore may depend on the spatial distribution of tumor cells within tissue. Using simulations we demonstrate that ∆R2* is non-linearly related to cell density, with the greatest influence occurring at cell volume fractions between 40 60%. We also show that the spacing of cells within a voxel can alter ∆R2* values by as much as 50% for spacing variations on the order of the cell size.