Quantitative Accuracy of Temporally Constrained Reconstruction in Dynamic Contrast Enhanced MRI

Yiqun Xue¹, Jiangsheng Yu¹, Mark A. Rosen¹, Hee Kwon Song¹

Temporally constrained reconstruction (TCR) has recently been developed for dynamic MR imaging to achieve high image quality at high undersampling factors. However, whether this technique can achieve accurate quantitative MRI measurements has not been investigated. In this work, an enhanced simulation experiment was conducted to evaluate of the accuracy of TCR for the assessment of DCE-MRI perfusion parameters. Compared to simple undersampled and KWIC methods, the TCR method yields more accurate and precise perfusion measures, and is much less sensitive to different levels of image noise, Ktrans values, and tumor sizes.