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Abstract #1988

DCE-MRI for Predicting of Treatment Response of Head and Neck Squamous Cell Carcinoma

Steven K.K. Chow1, Ann D King1, David K.W. Yeung1, Jing Yuan1, Kunwar Bhatia1, Anil T. Ahuja1, Alexander C. Vlantis2, Brian K.H. Yu3

1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Sha Tin, N.T., Hong Kong; 2Department of Otorhinolaryngology Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong; 3Department of Clinical Oncology, The Chinese University of Hong Kong

We used DCE-MRI to examine whether this technique can be used to predict treatment response in head and neck cancer. We examined 19 primary and 21 metastatic nodal lesions. Despite no significant difference was found between Ktrans parameters of tumors with disease control and disease failure, there was a trend towards disease failure in tumors with a lower Ktrans mean, Ktrans skewness and Ktrans kurtosis. This study is ongoing and presently we could only report that there appears to be a trend towards treatment failure in primary and nodal metastases with lower Ktrans means.