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Abstract #2002

Magnetization Dispersion Effetcs on Quantitative Perfusion Imaging for Pulsed and Continuous Arterial Spin Labeling

Mustafa Cavusoglu1, 2, Rolf Pohmann2, Kamil Uludag3

1Biomedical Engineering, ETH Zurich, Zurich, Switzerland; 2High Field MR Center, Max Planck Institute, Tuebingen, Germany; 3Department of Cognitive Neuroscience, Maastricht Brain Imaging Centre (MBIC), Maastricht, Netherlands

The arterial transit time is a key local variable which has to be included in the kinetic models to estimate the CBF (f) in arterial spin labeling. Due to cardiac pulsation, non-uniform cross-sectional flow profile and complex vessel networks, the distribution of transit delay time has a statistical nature instead of being uniform. In this study, we have investigated the regional effects of magnetization dispersion for varying distances between tagging and imaging regions by implementing pulsed (PASL), pseudo-continuous (PCASL) and dual-coil continuous (DC-CASL) ASL encoding schemes.