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Abstract #2009

Improved Estimation of Venous Saturation Using simultaneous arterial And venous acquisition of T2

David D. Shin1, Thomas T. Liu1, Richard B. Buxton1, Guo Jia2, David J. Dubowitz1

1Center for Functional MRI, University of California, San Diego, La Jolla, CA, United States; 2Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States

A novel approach to TRUST (T2 relaxation under spin tagging) for measuring venous O2 saturation (Yv) is presented. Critical to the measurement of Yv is a calibration between R2v and Yv. Although several authors have published calibration data, this are critically technique dependent which limits its universal applicability. We present a theoretical framework and propose a method to measure a R2 difference between two vessels (deltaR2) which removes some of the potential systematic errors from a calibration that is not locally applicable. This reduces the number of fit parameters from 6 to only 3. Initial tests in vivo reveal a better estimate of Yv and OEF than those obtained by assuming universal applicability of all 6 fit parameters. An novel imaging technique (SAVANT) is presented that directly measured the required deltaR2 by Simultaneous Arterial and Venous AcquisitioN of T2