CBF Quantification in Infants Using Look-Locker ASL and a Single Blood Compartment Model

Laura M. Parkes¹, Helen Beaumont¹, Laurence Abernethy²

For accurate quantification of cerebral blood flow (CBF) using Arterial Spin Labelling, multiple time-point measurements are required, allowing estimation of arrival time and CBF. A standard sequence is time-inefficient as no signal is collected during the delay period. The Look-Locker readout offers a more efficient approach, but complicates quantification. The aim of this work is to develop a simplified quantification model for the Look-Locker signal using a single blood compartment model. The model is validated using data from a healthy volunteer at a range of flip angles and is applied to 9 infants during routine clinical practice.