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Abstract #2015

Long-Term Reproducibility of PCASL with a Background Suppressed 3D Single-Shot Readout Sequence

Maria A. Fernndez-Seara1, Marta Vidorreta1, Maite Aznarez-Sanado1, 2, Federico Villagra1, Maria A. Pastor1

1Neuroscience, Center for Applied Medical Research - University of Navarra, Pamplona, Navarra, Spain; 2Radiology, University of Pennsylvania, Philadelphia, PA, United States

Most previous reproducibility studies of Arterial Spin Labeling (ASL) have assessed within-session or short-term reproducibility (at 1 week intervals) in young volunteers. The purpose of this study was to assess long-term reproducibility at monthly intervals, in a group of older adults. Whole brain CBF measurements showed good reproducibility for the duration of the study period, with a wsCV of 10%. This information can be useful for planning longitudinal studies that are usually carried out during periods of several months.