Songlin Yu1, Rui Wang2, Dong Zhang, Rong Wang, Shuo Wang, Zhentao Zuo2, Lin Ai3, Bo Wang2, Danny J. J. Wang4, Jizong Zhao
1 Beijing Tiantan Hospital, Capital Medical University, beijing, China; 2The State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of; 3Beijing Neurosurgical institute; 4Department of Neurology University of California Los Angeles Ahmanson-Lovelace Brain Mapping Center
The major quantitative calculation error of regional cerebral blood flow (rCBF) using arterial spin labeling (ASL) may exist in the differences in arterial transit arrival time. In this study we applied pseudocontinuous ASL (pCASL) with four postlabel delay (PLD) times and correlated the CBF results with that of CT perfusion to determine the optimal PLD that can best reflect the hemodynamics in moyamoya patients. The results show that pCASL images obtained at 2 to 2.5s best correlate with CTP. CBF values obtained at 1.5s may underestimate CBF values while the values obtained at 3000ms begin to decrease, likely due to the relaxation of the labeled signal.
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