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Abstract #2023

Quantifying the Dynamics of the Cerebral Blood Flow Response to Hypoxia

Ashley D. Harris1, Kevin Murphy2, Claris Diaz1, Neeraj Saxena3, Judith E. Hall3, Thomas T. Liu4, Richard G. Wise1

1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom; 2 CUBRIC, School of Psycholog, Cardiff University, Cardiff, United Kingdom; 3Department of Anaesthetics, Intensive Care and Pain Medicine, Cardiff University, Cardiff, United Kingdom; 4Centre for Functional Magnetic Resonance Imaging & Department of Radiology, University of California San Diego, La Jolla, CA, United States

Cerebral blood flow data (ASL acquisition) was collected before, during and after a hypoxic challenge. Based on a model developed for blood flow in the middle cerebral artery, the dynamics of the CBF response to hypoxia is then used to quantify CBF dynamics in response to a hypoxic challenge and during the return to normoxia. The CBF response to hypoxia differs regionally and in comparison to bulk arterial flow. Interpretations and implications of these finding are then discussed.