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Abstract #2024

Validation of Quantitative Human Brain Perfusion Measurement with Intravoxel Incoherent Motion (IVIM), with a Hypercapnia and Hyperoxygenation Challenge.

Christian Federau1, Philippe Maeder1, Kieran O'Brien2, Patrick Browaeys1, Markus Klarhoefer3, Reto Meuli1, Patric Hagmann1

1Dept. of Radiology, CHUV, Lausanne, Switzerland; 2University of Geneva, CIBM, Switzerland; 3Siemens, Switzerland

Quantitative brain perfusion measurement remains a major challenge to currently available MR perfusion methods. The intravoxel incoherent motion (IVIM) method offers a non-invasive, alternative method to measure brain perfusion quantitatively, based on a bi-exponential fit of the relative signal obtained with an standard diffusion sequence for multiple b-values, usually between 0 and about 1000 s/mm2. We challenged the IVIM method with graded hypercapnia and hyperoxgenation in 7 healthy volunteers and report a statistically significant, graded increase of the IVIM perfusion parameters under hypercapnia, namely of the perfusion fraction f and of the pseudo-diffusion coefficient D*.