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Abstract #2026

Investigation of Physiological Parameters for Pulsed ASL in Calf Muscles.

Hou-Jen Chen1, 2, Graham A. Wright1, 2

1Sunnybrook Research Institute, Toronto, Ontario, Canada; 2Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

This work presented an optimization of Arterial Spin Labeling for peripheral limbs. The arterial and perfusion responses after exercise during temporary ischemia were characterized. Perfusion was also measured with different post-labeling delays in a paradigm where the hyperemia was prolonged. The blood velocity was used to estimate the ideal sequence repetition time and spatial extent of labeling. The image samples at different delays were used to estimate transit delay. Quantification of perfusion and the sensitivity to peripheral hyperemia can be improved by physiological optimization based on the data.