Abstract #2033

Perfusion in Murine Myocardium: A Retrospectively Triggered Look-Locker Arterial Spin Labeling Sequence Using Model Based Reconstruction

Fabian Tobias Gutjahr¹, Thomas Kampf, Patrick Winter, Cord Meyer, Christian Herbert Ziener², Xavier Helluy, Peter Michael Jakob,³, Wolfgang Rudolf Bauer⁴

¹Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany; ²DKFZ, Heidelberg; ³Magnetic Resonance Bavaria, Wuerzburg, Bavaria, Germany; ⁴Medizinische Klinik und Poliklinik I, Universittsklinikum Wuerzburg, Wuerzburg, Bavaria, Germany

A retrospectively triggered Inversion Recovery Snapshot Flash sequence is proposed for robust quantification of perfusion in murine myocardium. An external ECG signal is recorded for retrospective triggering. The sequence which maintains strict Look-Locker condition can be implemented on virtually any MRI system as it does not need advanced triggering capabilities. A reconstruction based on the framework of partially separable functions using Principle Component Analysis is used to interpolate missing k-space data.