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Abstract #2033

Perfusion in Murine Myocardium: A Retrospectively Triggered Look-Locker Arterial Spin Labeling Sequence Using Model Based Reconstruction

Fabian Tobias Gutjahr1, Thomas Kampf, Patrick Winter, Cord Meyer, Christian Herbert Ziener2, Xavier Helluy, Peter Michael Jakob, 3, Wolfgang Rudolf Bauer4

1Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany; 2DKFZ, Heidelberg; 3Magnetic Resonance Bavaria, Wuerzburg, Bavaria, Germany; 4Medizinische Klinik und Poliklinik I, Universittsklinikum Wuerzburg, Wuerzburg, Bavaria, Germany

A retrospectively triggered Inversion Recovery Snapshot Flash sequence is proposed for robust quantification of perfusion in murine myocardium. An external ECG signal is recorded for retrospective triggering. The sequence which maintains strict Look-Locker condition can be implemented on virtually any MRI system as it does not need advanced triggering capabilities. A reconstruction based on the framework of partially separable functions using Principle Component Analysis is used to interpolate missing k-space data.