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Abstract #2034

Pseudocontinuous ASL (PCASL) Combined with EPI, RARE and TrueFISP for High Resolution Multi-Orientation Mouse Brain Perfusion Imaging

Guillaume Duhamel1, Virginie Callot1, Patrick J. Cozzone1

1CRMBM, UMR 6612, CNRS, Aix-Marseille University, Marseille, France

Mouse models of human brain diseases are extensively studied with long scan time multimodal MR protocols that include functional, metabolic and structural approaches. To further describe the pathologies, there is a real need for a high resolution, sensitive method which allows assessing quantitative whole brain perfusion within a reasonable scan time. This work presents the use of the ubpCASL technique in combination with fast imaging sequences for the acquisition of high resolution quantitative CBF maps within a short scan time protocol. The pCASL inversion efficiency was measured and multi-orientation acquisitions were investigated